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    Faculty of Medicine and Health Sciences
    Human structure and repair
    Tissue engineering and biomaterials
    Assistant professor, group leader
    UZ Gent, C. Heymanslaan 10, Ingang 46, 6th floor, 9000 Gent, Belgium
    One of the current challenges of organoid and 3D microtissues fabrication is in their high variability and lack of tools for single cell real-time analysis. My team focuses on combining innovations in biosensors, fluorescence lifetime imaging microscopy (FLIM) and biofabrication fields to controllably produce intestinal organoid and 3D tumor cultures with known and controllable growth and metabolic characteristics. To solve this challenge, we develop multi-parametric 3D live imaging methodologies addressing analysis of organoid oxygenation, visualization of stem cell niche, labelling of specific cell types, their proliferation and metabolism. Using this approach, we aim to design ‘active’ biosensors scaffold materials, understand gut-microbiota interactions and physiological role of O2 gradients in the intestine and tumor microenvironment, in health and disease. Expertise & keywords: intestinal organoids, tumor spheroids, fluorescence lifetime imaging microscopy (FLIM), biosensors, hypoxia.

Ruslan Dmitriev leads the Tissue Engineering and Biomaterials group at the Department of Human Structure and Repair, Ghent University.

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